"Inflammation helps the gut ward off an infection, but too much of it can cause lasting harm," said study researcher Daniel Mucida, Associate Professor at Rockefeller University in the US.
Eat a balanced diet to maintain healthy gut
For some people, a bout of intestinal distress like traveller's diarrhoea leads to irritable bowel syndrome (IBS). Recent discoveries have given researchers a better idea of how this happens, and potential leads for new treatments. Scientists aren't sure exactly how this happens, but some think an infection may contribute to IBS by damaging the gut nervous system. The study, published in the journal Cell, takes a close look at why neurons in the gut die and how the immune system normally protects them.
The research from Rockefeller University on mice offers insight into IBS, a chronic inflammation of the intestinal tract and could point to potential new treatment approaches.
According to the researchers, in a healthy gut, the immune system must strike a careful balance between responding to threats and keeping that response in check to avoid damage.
"Inflammation helps the gut ward off an infection, but too much of it can cause lasting harm," said study researcher Daniel Mucida, Associate Professor at Rockefeller University in the US.
"Our work explores the complex mechanisms that prevent inflammatory responses from destroying neurons," Mucida added.
To understand the effects of an infection on the nervous system, the research team gave mice a weakened form of Salmonella, a bacterium that causes food poisoning, and analysed neurons within the intestine.
They found that infection induced a long-lasting reduction of neurons, an effect they attributed to the fact these cells express two genes, Nlrp6 and Caspase 11, which can contribute to a specific type of inflammatory response.
This response, in turn, can ultimately prompt the cells to undergo a form of programmed cell death.
When the researchers manipulated mice to eliminate these genes specifically in neurons, they saw a decrease in the number of neurons expiring.
"This mechanism of cell death has been documented in other types of cells, but never before in neurons," said study researcher Fanny Matheis.
"We believe these gut neurons may be the only ones to die this way," Matheis added.
It's not yet clear exactly how inflammation causes neurons to commit cell suicide, yet the researchers already have clues suggesting it might be possible to interfere with the process.
The key may be a specialised set of gut immune cells, known as muscularis macrophages.
Previous work in Mucida's lab has shown that these cells express inflammation-fighting genes and collaborate with the neurons to keep food moving through the digestive tract.
If these neurons die off, as happens in an infection, a possible result is constipation -- one of a number of unpleasant IBS symptoms.
In their recent report, the team demonstrated how macrophages come to the neurons' aid during an infection, ameliorating this aspect of the disorder.
Their experiments revealed that macrophages possess a certain type of receptor molecule that receives stress signals released by another set of neurons in response to an infection.
Once activated, this receptor prompts the macrophage to produce molecules called polyamines, which the researchers think might interfere with the cell death process.
In other experiments, the researchers found that Salmonella infection alters the community of microbes within the guts of mice -- and when they restored the animals' intestinal flora back to normal, the neurons recovered.
How to take care of gut health
Lifestyle coach Luke Coutinho is of the belief that inflammation is the root cause of most diseases. Inflammation is what worsens gut health as well. A healthy gut is synonymous to good overall health, and healthy digestion. Following are some effective ways to take care of your gut health:
1. Eat probiotics and prebiotics
Probiotics provide your gut with good bacteria and help in improving gut flora. Good bacteria in probiotics like curd, kefir, kombucha, kimchi and pickles help the gut in getting rid of excess bad bacteria. Prebiotics, present in foods like asparagus, onions, oats and bananas, are ingestible fibres that can also be good for your gut health.
2. Chew your food properly
According to Luke, the first step to a healthy digestion begins in the mouth, and if you don't chew your food properly, then it is going to be bad for your digestion as well as gut health.
3. Eliminate food triggers
If you have poor gut health or a leaky gut, you should stay away from triggers like gluten, dairy, caffeine, sugar, alcohol, meat and nightshade foods. These foods, according to Luke, are difficult to digest and must be avoided by people with poor gut health.
4. Consume a balanced diet
A balanced diet has properly distributed nutrients. Every nutrient plays different role for your body. A healthy and balanced will promote a healthy gut. Some of the foods which can leave a soothing effect on your gut include garlic, pineapple, apple cider vinegar, broccoli, ginger and many more.
(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)
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