Vitamins improve tuberculosis treatment

Supplementing the diet with nutrients, including selenium and vitamins A, B complex, C, and E, improves the outcomes of patients being treated for tuberculosis. The nutritional status is a very important predictor of clinical outcomes in patients with infections. The researchers hypothesised that nutrient supplements would reduce the risk of disease complications and death in patients treated for tuberculosis. They tested their hypothesis in a study of 887 patients. The use of the nutrients was associated with a slight reduction in the risk of tuberculosis treatment failure and with a 45 percent reduction in the odds the disease would return after successful treatment. This latter effect was stronger in the subgroup of patients who were infected with HIV, the virus that causes AIDS. Tuberculosis is a frequent complication in HIV-infected patients. Nutrient supplementation was also tied to a reduced risk of tuberculosis complications occurring outside of the lungs. Beneficial immune system effects were noted in HIV-negative patients, but not in those infected with the virus. Nutrient supplements had no effect on death rates or on the progression of HIV disease. A single study like above is usually not sufficient to provide general recommendations. However, this relatively inexpensive intervention does seem promising as a potential way to improve the outcome of patients receiving anti-tuberculosis treatment. Also, the findings represent a true effect and that nutrient supplementation could be an important (additional) therapy for patients with tuberculosis.

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