Oestrogen therapy and incontinence

Oestrogen is not a useful treatment for a leaky bladder in postmenopausal women. In fact, this hormone therapy seems to increase the risk of urinary incontinence in healthy women and worsen it in those who already have this problem. Oestrogen with or without progestin should not be prescribed for the prevention or relief of urinary incontinence. Researchers from the Wayne State University in Detroit, did a study with 23,296 healthy postmenopausal women. The subjects were randomly selected to receive oestrogen plus progestin, oestrogen alone, or inactive "placebo". Earlier results have linked oestrogen therapy to an increased risk of heart attack, stroke and breast cancer. Hormone therapy was associated with an increased risk for all types of urinary incontinence, particularly stress incontinence in which leakage occurs with actions that raise abdominal pressure, such as laughing or coughing. For women who already had urinary incontinence, treatment with either oestrogen or oestrogen plus progestin was associated with increasing urinary frequency. Moreover, such therapy was tied to urinary incontinence that limited daily activities and reduced quality of life.

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