Obese siblings of diabetic children at risk

Compared with other overweight children, overweight siblings of children with type 2 diabetes mellitus have a significantly higher prevalence of abnormal glucose tolerance, a risk factor for diabetes. Researchers in America studied 62 obese children, aged 8 to 17 years, who had at least 1 sibling aged 12 years or older. Twenty children had a sibling with diabetes; 42 acted as controls. It was found that the prevalence of abnormal glucose tolerance was 40 percent in the group with diabetic siblings and 14 percent in the controls. However, there were no differences in insulin resistance or in haemoglobin A1c (glycosylated haemoglobin - a long tem measure of blood sugar control in the preceding 3 months) between groups. The researchers concluded that the 'at risk' siblings had a unique combination of genetic and environmental risk factors. This group also represented a particularly high-risk population to target for screening and type 2 diabetes mellitus prevention.

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