Growth hormone increases height

Children who are short for no apparent medical reason can get a boost in height from growth hormones, according to recent research. Researchers from the National Institute of Child Health and Human Development, Maryland, USA, conducted a trial involving 68 children between 9 and 16 years of age who were short in stature but not deficient in natural growth hormone. They were given growth hormone or an inactive placebo every week until they were near adult height. At the end of the study, adult height measurements were available for 33 of the children, who had participated in the trial for an average of 4.4 years. It was found that the growth hormone group achieved a significantly greater adult height than the placebo group, although the treated group was still shorter than average. Because adult height information was unavailable for so many subjects, the researchers performed a modified analysis of 62 participants treated for at least 6 months. This analysis indicated a similar growth hormone effect on last observed height and no important dropout bias. The current study demonstrated that growth hormone treatment increases adult height in children with short stature around the time of puberty. Also, the findings provided the best estimate to date of the increase in height that can be expected from growth hormone therapy. But the researchers do caution against the inappropriate use of growth hormone and indicate the need for further research.

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