Gene Editing Can Curb Autism Symptoms, Here's How
Scientists have found that editing a gene in the brain can help decrease the repetitive behaviours -- a symptom of autism spectrum disorders. The team is believed to be the first to successfully edit a causal gene for autism in the brain and diminish symptoms.
Editing a gene in the brain might cure the symptoms of autism
- A study shows that autism symptoms can be genetically treated
- Gene editing can curb autism symptoms
- Editing a gene in the brain can diminish autism symptoms
In a mice model with fragile X syndrome -- an inherited cause of autism spectrum disorders, the researchers targeted Cas9 at a molecule called mGluR5 that is excitatory -- it increases communications between neurons. The approach worked.
The rodents' digging behaviour slowed by 30 per cent and the leaping behaviour was reduced by 70 per cent, Lee said, in the paper described in the journal Nature Biomedical Engineering.
The team is believed to be the first to successfully edit a causal gene for autism in the brain and diminish symptoms. Significantly, the effect is permanent, Lee said.
"The approach can also be used to treat other diseases including many neurological diseases such as epilepsy, and the brain cancer glioblastoma, if we know the gene target," she said.
(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)
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