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Is it safe to take Wysolone and Azoran?

Q: My 46 years old wife is suffering from tuberculosis (TB) and is undergoing treatment. She is taking medicines - Wysolone and Azoran for tuberculous meningitis for the last 10 months. She is also diagnosed with systemic lupus erythematosus (SLE). She is experiencing swelling on her right ankle once in a month. Is it safe to take Wysolone and Azoran?

A:Wysolone is the trade name for the corticosteroid medicine prednisolone. Prednisolone in the context of tuberculous meningitis is used to reduce the inflammatory reaction (both systemically and within the central nervous system) induced by the tubercolous infection, and thereby reduce the chances of complications (such as obstructive hydrocephalous and vasulitis induced stroke) and improve clinical outcome. Azoran, on the other hand, is the trade name for the immunosuppressive medicine azathioprine. SLE or systemic lupus erythematosus is an auto-immune disease, where azathioprine is used to reduce the auto-immune response. There does not appear to be any drug interactions between prednisolone and azathioprine. However, since both prednisolone and azathioprine are immunosuppressive agents individuals on these medications need to be closely monitored for side effects such as infections, haematologic side effects (e.g. leucopenia).

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