Q: Could you please let me know the long term effect of taking Regestrone. I am 36 years old and take about 5 tablets every month for 3 months. But I am no longer on that pill for the last two months. I used to get my periods every 24 days all my life, but since the last month it is way over 24 days. Has my cycle changed forever and would this affect my chances to conceive? I was also diagnosed with having polycystic ovary and was planning to take Fertyl starting from my next cycle, would that in anyway affect my periods? And what are the chances of me getting pregnant?

A:Regesterone is a brand name that contains a medicine called norethisterone. It is a progesterone female hormone. Menstrual cycle change/irregularity is a common side effect for a few months but it will go away. Clomiphene sold under various brand names (such as Fertyl, Siphene) is used in cases of anovulatory infertility including infertility caused by Polycystic Ovarian Disease. The first course should consist of 50 mg daily for 5 days; incase conception does not take place two more courses can be given : 100mg daily for 5 days. The courses should be 8-10 weeks apart. No benefit occurs after three courses. Clomiphene can result in mennorhagia (increased cycle bleeding) in a very small number of cases (1.3%) but it is harmless. The chances of success of clomiphene therapy depend on accurate diagnosis and appropriate therapy. There can be many causes of female infertility and only one of them is anovulatory infertility.