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Is it safe to administer progesterone vaginally?

Q: My 26 years old wife is 161 cm tall and weighs 56 kg. She has been diagnosed with PCOD. The gynaecologist asked her to take Nacfil 600 twice a day for three months and last month she was prescribed Siphene 50 for ovulation. My wife is pregnant now and her doctor has asked her to take folic acid and progestone 100 by vaginal administration. But I have read that progestone vaginal administration is not advisable for patients having cystic problems. Please tell whether or not is my wife on right treatment?

A:Women who are diagnosed to have PCOS and get pregnant after ovulation induction usually require luteal support to maintain pregnancy. So do not worry, the treatment is OK, and 100 mg is the lowest dose. Some women require 200 or 300 mg, the dosage can be adjusted according to progesterone levels. Ask your doctor for details; it is impossible to give all details without physical examination.

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