Q: I am taking Alprazolam 0.25 mg + Propanalol 20 mg from the past 2.5 years. But I am unable to withdraw due to terrible withdrawal symptoms. Kindly advise.

A:It is not clear from your message whether you are taking alprazolam and propranolol separately or in a combination pill. The combination of alprazolam with propranolol is illegal and not permitted anywhere in the world. In any case such a therapy is not indicated in depression. Extended use of alprazolam causes dependence. You can gradually reduce the dose such as 0.125 mg for 7 days, then 0.125 mg on alternate days for 10 days and then terminate the dose.