Q: I shall be much obliged if you could inform me about the efficacy of both Prothionamide and Ethionamide with respect to second line drug therapy for TB and which one is superior?

A:Ethionamide (Brand name: Ethide by Lupin) and prothionamide (Brand name: Prothicid) are to be used if other conventional drug therapies have either failed or are contraindicated. They are quite effective, but it all depends upon the sensitivity of the tuberculosis germs.