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What is tubulointerstitial nephritis?

Q: My 29 years old wife is suffering with tubulointerstitial nephritis antigen, which was found in a renal biopsy. The doctor who is treating her has given some tablets, which are Amtas AT 25 half twice daily, Omnacortil 40 mg once daily, Cardace 2.5 once daily and Losar 25 mg twice daily for five days after that which he changed the Omnacortil level from 40 mg to 30 mg then 25 mg then 20 mg, 15 mg, 10 mg and last 5 mg; Amtas AT - 25 half daily and Losar and Cardace 2.5 are same as earlier. Please tell what is tubulointerstitial nephritis? Is it treatable?

A:Acute tubulointerstitial nephritis is usually an allergic reaction of the kidney to a drug and if treated early is usually reversible & the patient recovers. The treatment is a short course (3-4 weeks) of steroids (omnacortil). The recovery will depend on the kidney biopsy findings and if there are any chronic changes in the biopsy, they usually are not reversible. In some patients the tubulo-interstitial nephritis is idiopathic (no cause found) or part of various systemic diseases like auto-immune disorders (systemic lupus erythematosus).


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