Q: Whenever any person shakes hand with me or touches my hand, they remark that my hands are very rough. What could be the possible reason for this roughness? Time and again, I have tried to smoothen the hand-surface by applying some moist-soap and body-oil but have not been quite successful. What can be done for the same?

A:Most likely, you are having keratoderma that is thickening of palmar skin. You may use a moisturiser cream like Moisturex or Cotaryl cream daily and shake hands softly.