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How is the dose of Valparin decided for children?

Q: My 6 years old son weighs 23 kg and is having epilepsy for the last 4 years. He becomes hyperactive about a week or 10 days before a seizure. He has been taking 5 ml of Valparin twice a day (morning and evening) for the last 2 years. How can I know when I should see the doctor for the review of the dosage? What is the criterion of deciding the dosage of Valparin for children? I came to know that it depends on the weight of the patient. Please clarify.

A:Valparin is the brand name; the name of the medicine is valproic acid. The dose for patients over or about 23 kg (irrespective of weight) is initially 400 mg daily i.e. 200 mg twice daily. Valparin suspension contains 200 mg per 5 ml. Thus the dose being given is correct. The usual dose in children is 20-30 mg per kg of the body weight.


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