Can I have sex if I have an enlarged spleen?
Q: I have an extremely bad case of mono/epstin-barr virus. I have an enlarged spleen1. Is it OK to have sex in this case?
A:The main danger of an enlarged spleen is traumatic rupture. For this reason, we recommend that contact sports, which can result in a direct blow to the spleen, should be avoided. However, sexual contact without overdue pressure on the spleen should be OK.