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Do I need to undergo kidney transplantation?

Q: I am a 25 years old female diagnosed with leaking protein (5.4 grams per day in urine). Now I am taking steroids for last two months and it has reduced by 75 percent. Do I need to undergo kidney transplantation?

A:You have an underlying chronic kidney disease (CKD) characterized by massive amount of protein leakage into the urine. These types of disease process sometimes called "Nephritis" involves increased swelling and inflammation of filtering cells in the kidney which often responds well to high dose steroids. You have one of these types of kidney disease which can definitively be ascertained by Kidney biopsy. The chances of progression of your CKD eventually to the stage of kidney failure requiring dialysis or the transplant, would depend upon: the type and the severity of disease process (known from biopsy results) and the level of current filtering function (based on serum creatinine value) at the time of initial disease diagnosis.

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