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What are the causes?

Written by : DoctorNDTV Team

Azoospermia may be due to a number of factors. The three major causes for lack of sperm production are hormonal problems, testicular failure, and varicocoele.

  1. Hormonal problems

    Pituitary hormones stimulate the testes to produce sperm. If these hormones are absent or decreased, the testes will not produce sperm in the optimum numbers. Androgens or steroids, taken either by mouth or by injection for body building, lowers the production of hormones necessary for sperm production.

  2. Testicular failure

    This generally refers to the inability of the testicle to make adequate numbers of mature sperm. The failure may occur at any stage in sperm production for a number of reasons. The testicle may completely lack specific cells (the seminiferous epithelium) that divide to become sperm or the sperm may not be able to complete their development. The latter may be caused by genetic abnormalities, hormonal factors, or varicocoeles.

  3. Varicocoele

    Varicocoeles are dilated veins in the scrotum (comparable to a varicose veins in the leg), which become dilated, and blood does not drain properly. This allows extra blood to pool in the scrotum, which has a negative effect on sperm production. This condition is the most common reversible cause of male infertility and may be corrected by surgery.

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