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Which diseases are associated with an elevated WBC count and thrombocytopenia?

Q: What other diagnosis, besides leukaemia, is associated with an elevated white blood cell count and decreased platelets/?

A:These values have to be correlated with the age of the patient, his/her history and clinical profile to give a meaningful differential diagnosis. However, some of the conditions that come to mind include:

  • Infections: Hepatitis, CMV, TB, fungal disease, parasites etc
  • Sepsis
  • TTP and related states
  • Acute inflammatory states (Auto-immune, drugs, poisonings, toxins etc)
  • Myelodysplastic syndrome
  • Acute leukaemia
  • Chronic leukaemia
  • Myeloproliferative disorders
  • Lymphomas
  • Metastatic tumours

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