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Why am I getting acne with anti-TB drugs?

Prof Jayakar Thomas
Senior Consultant Dermatologist,
Kanchi Kamakoti Child Trust Hospital,
Chennai

Q: I am a 28 years old girl suffering from abdominal tuberculosis (TB) and the doctor gave me AKT4. After taking this I am suffering from acne, which I never used to have before. The doctor told me that it is because I am taking a drug called Isoniazid, which is causing the problem. Is it true? I had a very clear skin and but now I am suffering with more pimples which is making my face worse. Please advise.

A:You have been rightly informed that Isoniazid can cause acne-like lesions. But you should not stop Isoniazid.It is suggested that you use a topical retinoid like tretinoin or adaplaene until you complete the course of anti-tuberculosis drugs and continue even for some time later. Please use the topical application only at night and under the strict observance of a dermatologist.