How many cases of vitamin B12 deficiency have been reported so far?

Q: How many cases of vitamin B12 deficiency have been reported so far?

A:The main source of vitamin B12 (cobalamin) in humans is the consumption of meat, poultry and dairy products. Its deficiency can be caused by decreased ingestion (poor dietary intake), impaired absorption (failure to release B12 from protein, intrinsic factor deficiency, chronic pancreatic disease, intestinal parasites, other intestinal diseases), or impaired use (congenital enzyme deficiencies, lack of transcobalamin II, administration of nitrous oxide). The recommended daily intake varies with age and is about is 2 mcg/day in adults; 2.6 mcg/day in pregnant and lactating women; and 0.7 mcg/day in children.

The prevalence of B12 deficiency in the general population has not been well established because a universally accepted normal B12 level has not been defined. Prevalence in the general population varies from 3% to 5%, and from 5% to 20% among people older than 65 years. Vitamin B-12 deficiency is a worldwide problem, particularly in the newborn period due to the combined effects of poor maternal diet and congenital deficiencies of transcobalamin. Pernicious anemia is a common cause of megaloblastic anemia especially in persons of European or African descent. Dietary vitamin B12 deficiency is a serious problem in India, Mexico, Central America, South America, and some areas of Africa. The increase in vegetarianism is related to an increase in vitamin B12 deficiency, especially concerning in breastfed infants of vitamin B12–deficient mothers.

In India, a hospital population radio assay study with a cutoff of 200 pg/ml found a vitamin B12 deficiency in 0.88% of patients, with borderline values in 3.8%. Some evidence suggests South Asians, lacto vegetarians, and in particular South Asians who are lacto-vegetarians are at greater risk of B12 deficiency. One study found that about 38% of people in western India followed a lacto-vegetarian diet and that 47% of the study population (60% of vegetarian and 39% of non-vegetarian people) was B12 deficient. Another study found that South Asian men in the United Kingdom had lower mean B12 levels than European controls (270 pmol/L vs 357 pmol/L). In Asia, Indians had lower B12 levels than Chinese or Malays.

Some Indian studies on this topic are as below:

Indian Series	Year	Vit.B12 def. (%)
Bhende et al	1965	7.0
Mittal et al	1969	22.4
Sarode et al	1989	76.4
Gomber et al	1998	50.0
Gomber et al	1998	36.6
Chaudhry MW	2001	19.0
Chandra et al	2002	32.0
Khanduri et al	2005	33.0