Can excessive dose of insulin affect conception?

Q: I have a query related to excess insulin usage. My sister-in-law is not a diabetic and has no family history either. However, she was given high dosage of insulin during a particular treatment for infertility. Can this high insulin dosage affect her becoming pregnant and if at all she conceives, what are the probable dangers.

A:Since your sister-in-law is not a diabetic and as it appears that shehas one episode of excess insulin, I personally feel that there should be noproblem of her future fertility being affected due to this. What amazes me iswhy would a non-diabetic be administered insulin and that too in excess! Iam sure that the subsequent hypoglycaemic attack may have scared the wits outof her and her family!! What is more pertinent is that both she and herhusband be investigated thoroughly for the common causes of female and maleinfertility.An estimation of glycosylated haemoglobin would be helpful to know herimmediate past blood sugar status, and if found abnormal, a glucose tolerancetest be considered. This is important, as abnormally high blood sugar levelsif present during the periconceptional and immediate postconception period,have shown to be associated with an increased incidence of congenitalanomalies in the fetus.