Weight gain increases kidney disease risk

Even small weight gain among healthy men may make them vulnerable to chronic kidney disease (CKD).Obesity is a known risk factor for CKD, but the impact of weight gain in normal-weight individuals without high blood pressure or diabetes is not known. To assess the impact of weight gain among healthy men on the risk of developing CKD, Korean researchers followed 8792 healthy men, aged between 30 and 59 years, with no known risk factors for CKD. The participants were required to undergo periodic health examinations that monitored their blood pressure and body mass index.During 35,927 person-years, 427 new cases of CKD developed. Body mass index (BMI) categories at the start of the study (i.e., underweight, normal weight, overweight, obese) were not found to be significantly associated with the development of CKD. Further, men who lost or gained a lot of weight (more than 0.75 kilograms, or 1.7 pounds, per year) had the highest risk of developing CKD. Increased risk was seen among men with even small weight changes. The lowest risk observed was among those who gained or lost as little as 0.25 kilograms, or 0.6 pounds, per year. The findings suggest that weight gain within the normal weight range is one of the risk factors of developing CKD and initial low body weight does not fight against the ill effects of weight gain. The researchers recommended that even lean individuals should take precautions against weight gain to cut down the risk of kidney disease.

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