Female hormone may treat brain injuries
Treatment with progesterone safely reduces the risk of death and disability in people who suffer a traumatic brain injury.
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Treatment with progesterone, a hormone that prepares the womb for pregnancy, safely reduces the risk of death and disability in people who suffer a traumatic brain injury.
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. It has been noted that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration and low cost.
Researchers from the Emory University in Atlanta included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive placebo. The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
Aside from some minor inflammation at the progesterone injection site, the side effects seen with the hormone were comparable to those observed with placebo. No serious side effects were seen in either group. The researchers were able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to get no benefit from the hormone.
The above findings are encouraging and indicate the need for additional studies to investigate this topic further.
Animal studies have indicated that giving progesterone soon after injury reduces brain swelling, prevents nerve death and improves functional outcomes. It has been noted that progesterone's advantages over other potential treatments include its ability to quickly enter the brain, history of safe use, ease of administration and low cost.
Researchers from the Emory University in Atlanta included in their study 100 adults with brain injury who reached the emergency department within 11 hours of injury. Patients were randomly assigned to receive an intravenous dose of progesterone or inactive placebo. The death rate in the 30 days after injury was 13 percent in the progesterone group compared with 30 percent in the comparison group. This suggests that progesterone cut the risk of death by 57 percent.
Aside from some minor inflammation at the progesterone injection site, the side effects seen with the hormone were comparable to those observed with placebo. No serious side effects were seen in either group. The researchers were able to contact 92 percent of patients who survived 30 days. There was evidence that progesterone improved the recovery of patients with moderate brain injury. Patients with severe injury seemed to get no benefit from the hormone.
The above findings are encouraging and indicate the need for additional studies to investigate this topic further.
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