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What is the cause and permanent treatment for recurrent malarial fever?

Thursday, 19 May 2005
Answered by: Dr. D.D.K. Rolston
Consultant Physician,
Cleveland Clinic Foundation,
Cleveland, USA
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Q. I had malarial fever 8 months back and I took some medicines and recovered. Then 6 months back I again got the same malarial fever. I was admitted to the hospital for 5 days and after treatment I recovered. Then again in a 2 months span I got the same malarial fever so I went for a thorough test and from the report the doctors said that a virus Plasmodium vivax is in the liver. He said it is caused by mosquito bites so I went through a 15 days course of medicines. How can I be sure that the same malarial fever will not attack me in future? What steps do I need to take to recover from the fever completely?

A.  The finding of Plasmodium vivax (a parasite) in your blood confirms the diagnosis of malaria. This organism is usually transmitted by the bite of Anopheles mosquitoes but can be transmitted by blood transfusion as well. The vivax form of the parasite is one which can replicate in the liver so that there can be recurrent attacks of malaria. The way to treat this infection is for 2 weeks with a combination of chloroquine and primaquine which is what I assume you were prescribed. A recurrence may indicate that either the parasite was not completely eliminated as when it is resistant to the medication prescribed or that it was not a true recurrence and that you got re-infected. In certain countries including India, chloroquine resistant parasites are emerging. If this be the case you will need to be treated by different medications. In order to prevent a re-infection in case you get bitten by an infected mosquito again, you should apply a mosquito repellant, wear long sleeved shirts and long pants especially at dusk when these mosquitoes are most active and you should sleep under a mosquito net. There is no vaccine available at the present time although many researchers are working on developing one.

A.  The finding of Plasmodium vivax (a parasite) in your blood confirms the diagnosis of malaria. This organism is usually transmitted by the bite of Anopheles mosquitoes but can be transmitted by blood transfusion as well. The vivax form of the parasite is one which can replicate in the liver so that there can be recurrent attacks of malaria. The way to treat this infection is for 2 weeks with a combination of chloroquine and primaquine which is what I assume you were prescribed. A recurrence may indicate that either the parasite was not completely eliminated as when it is resistant to the medication prescribed or that it was not a true recurrence and that you got re-infected. In certain countries including India, chloroquine resistant parasites are emerging. If this be the case you will need to be treated by different medications. In order to prevent a re-infection in case you get bitten by an infected mosquito again, you should apply a mosquito repellant, wear long sleeved shirts and long pants especially at dusk when these mosquitoes are most active and you should sleep under a mosquito net. There is no vaccine available at the present time although many researchers are working on developing one.

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